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Seroxat group actions uk. This study is a controlled multicenter trial. The study protocol is available at NEJM.org. The trial was conducted from June 2004 to May 2007. The primary efficacy outcome was number of hospitalizations and deaths; secondary efficacy outcomes included all-cause mortality, non-fatal myocardial infarction, and stroke. The primary outcome was adjusted for age, sex, and hospitalization. Secondary outcomes included the number and Seroxat 180 Capsules 10mg $380 - $2.11 Per pill duration of use lipid-modifying therapies, a composite of and all-cause mortality at 1 year. Patients were assigned to 1 of 4 treatment groups: aqueous-gel lipid-modifying agents, osmotic diuretics, hydrochlorothiazide-antifibrinolytics, and potassium-sparing diuretics. Primary (Cohort) Analysis The primary analysis was a 2-by-2 factorial of the risk primary end point according to treatment group. We used a multivariable Cox proportional-hazards model with the log link function to compare the number of hospitalizations, death, nonfatal myocardial infarction, or stroke in patients each group with the log 2 odds ratio that was associated with the use of each lipid-modifying therapy. We were not able to adjust the Cox model for multiple comparisons because of the relatively large number patients in the study. The primary analysis was performed seroxat farmaco generico at each study site. We performed a 2-sided P value of less than.05 to signify statistical significance. Secondary (Cohort) Analysis Secondary analyses were performed at each site. The secondary analyses were used to evaluate whether use of a lipid-modifying therapy led to more adverse events in patients with an elevated lipoprotein(a) level (ie, those with triglycerides >200 mg/dL). The secondary analysis was conducted at the end of trial (month 4), and the primary analysis was conducted at the end of year 2 (February 2007). We performed 2-sided P values of less than.05 to signify statistical significance. The baseline lipid-modifying therapy group did not differ from the placebo group in any of generic drugstore online the primary or secondary analyses. We conducted a 2-sided P value of less than.05 to signify statistical significance. We conducted a 2-sided P value of.05 or less to signify statistical significance. We conducted a 2-sided P value of more than.05 to signify statistical significance. We conducted a 2-sided P value of greater than.05 to signify statistical significance. To assess the overall risk of bias, we conducted a funnel plot (a 2-sided P nombre generico de seroxat value of less than.05 indicating substantial asymmetry and a P value of.05 or greater indicating substantial asymmetry) and an Egger test. Results Patient Characteristics In the multivariable-adjusted model, aqueous-gel lipid-modifying agents were associated with a significantly lower number of total hospitalizations and deaths, as well a significantly lower risk of nonfatal myocardial infarction, at 1 year compared with hydrochlorothiazide-antifibrinolytics. The number of hospitalizations and deaths were not significantly different between patients assigned to osmotic diuretics and those assigned to hydrochlorothiazide-antifibrinolytics. The total number of hospitalizations and deaths was significantly lower for patients assigned to aqueous-gel lipid-modifying agents than for those assigned to hydrochlorothiazide-antifibrinolytics (P =.03 for trend) (Figure 1). Hematologic and Clinical Factors A comparison of the number hospitalizations and relative risk of hospitalization death between the aqueous-gel lipid-modifying agent group and the hydrochlorothiazide-antifibrinolytic demonstrated a significantly lower number of hospitalizations (hazard ratio, 0.59 [95% confidence interval, 0.37-0.93]) and deaths (hazard ratio, 0.55 [95% confidence interval, 0.34-0.85]) in patients assigned to aqueous-gel lipid-modifying agents compared with hydrochlorothiazide-antifibrinolytics (Table 2). The absolute risk difference of hospitalization and death was not different between the groups.
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