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Buy valacyclovir (5 mg/kg/5 days, two injections), followed by intramuscular infusions of placebo, valacyclovir, and valproic acid. Two subjects experienced mild side effects (decreased appetite, dizziness, and nausea) after three weeks of treatment, although at the time of writing two authors were unaware of any adverse effects since the onset of treatment. After an additional 4 weeks of intramuscular infusions, there were no further adverse effects reported. The primary outcomes were both bodyweight and resting energy expenditure (EER). This trial was registered at clinicaltrials.gov as NCT01553872. No other relevant data are available. Results and Discussion The primary outcome measures were bodyweight and resting energy expenditure (REE). Bodyweight was measured after 24 h the last injection (d 0). Two subjects had lost >2.5 kg over the course of treatment period; one subject only had a >1 kg loss but reported feeling "normal". REE was initially measured after 16 h d 0, in the laboratory following oral ingestion of either valacyclovir or placebo, and this was determined to be equivalent in both groups, but over the next two months REE fell significantly as expected. The remaining participants maintained average bodyweight, but their REE did not, continuing to trend downwards across time. These results are summarized in Figure 1, which summarizes results for each outcome individual participants. FIGURE 1 View largeDownload slide Mean (±SD) bodyweight and resting energy expenditure (REE) of subjects (n = 24) randomized to valacyclovir (5 mg/kg/5 days, two injections), followed by intramuscular infusions of placebo, valacyclovir, and valproic acid. Two subjects experienced mild side effects (decreased appetite, dizziness, and nausea) after three weeks of treatment, although at the time of writing two authors were unaware of any adverse effects since the onset of treatment. After an additional 4 weeks of intramuscular infusions, there were no further adverse effects reported. The primary outcomes were both bodyweight and resting energy expenditure (EER). This trial was registered at clinicaltrials.gov as NCT01553872. No other relevant data are available. FIGURE 1 View largeDownload slide Mean (±SD) bodyweight and resting energy expenditure (REE) of subjects (n = 24) randomized to valacyclovir (5 mg/kg/5 days, two injections), followed by intramuscular infusions of placebo, valacyclovir, and valproic acid. Two subjects experienced mild side effects (decreased appetite, dizziness, and nausea) after three weeks of treatment, although at the drug stores in montreal canada time of writing two authors were unaware of any adverse effects since the onset of treatment. After an additional 4 weeks of intramuscular infusions, there were no further adverse effects reported. The primary outcomes were both bodyweight and resting energy expenditure (EER). This trial was registered at clinicaltrials.gov as NCT01553872. No other relevant data are available. Valacyclovir, but not placebo, increased plasma valproate levels by 24 h post-injections (Figure 2). A secondary measure of valproate absorption across the serum was measured 3 d after treatment by LC-MS, with a correlation coefficient of 0.70.

Valacyclovir is an antiviral drug. It slows the growth and spread of the herpes virus to help the body fight the infection. Valacyclovir is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles (herpes zoster) in adults. Valacyclovir is used to treat cold sores in children who are at least 12 years old, or chickenpox in children who are at least 2 years old.

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